Herbicide-resistant Italian ryegrass has long infested North Carolina. In particular, the southern Piedmont has widespread ALS resistance (Osprey and PowerFlex) and spotty ACCase (Hoelon and Axial XL) and glyphosate resistance. For farmers battling Italian ryegrass biotypes that are resistant to glyphosate, ALS, and ACCase herbicides, paraquat is the last line defense for emerged Italian ryegrass. However, paraquat-resistant Italian ryegrass has recently been confirmed in North Carolina. This presentation highlights the importance of avoiding paraquat resistance and potential tactics for managing multiple-resistant Italian ryegrass.