Lorenz reviews management of key insects on cotton in the Mid-South, including the tobacco thrips, tarnished plant bug (TPB), stink bug, leaf-footed bug, bollworm, and spider mite. He identifies the TPB as the most important pest and states that factors influencing management include landscape diversity, planting date, tillage practices, pest management practices for other crops, environment/weather, and wild hosts. Lorenz demonstrates sampling of early season plant bugs and of mid- and late-season plant bugs and reviews the efficacies of products for TPB management. For the bollworm, Lorenz reviews 2019 thresholds and treatment protocols, efficacy data for selected insecticides, and management strategies. Lorenz calls spider mites “budget busters” and recommends rotating chemistries in response to “bounce back” of populations.