Proper nutrient management in cotton is important for attaining high yields. Utilization of precision soil sampling strategies is critical to determine spatial nutrient variability within fields and to inform variable-rate fertilizer applications for site-specific nutrient management. This presentation provides information on the efficacy and economics of soil sampling on different grid- and zone-based soil sampling methods with some practical considerations for growers to consider and adopt efficient and cost-effective precision soil sampling methods on their farms.