This presentation will help consultants, growers, and other practitioners in the midsouthern and southeastern U.S. manage Italian ryegrass that is resistant to glyphosate. Dense populations of glyphosate-resistant Italian ryegrass are problematic for producers. This weed can jeopardize burndown programs, and few affordable postemergence herbicides are available. This presentation summarizes the known distribution of this weed and research addressing its management. The practitioner should know more about the negative impact of ryegrass to cotton and have adequate information to minimize these effects.