Fusarium oxysporum f. sp. vasinfectum (FOV) Race 1 interacts with the root-knot nematode to cause Fusarium wilt disease on cotton. Field trials conducted in 2019 to screen cotton varieties for resistance to FOV and to the root-knot nematode showed that varieties with resistance to both the fungus and the nematode had the lowest levels of plant death and the smallest nematode populations in the soil. Variety selection is the most effective strategy for managing Fusarium wilt.