This presentation provides an overview of Pythium leak of potato. Growers, consultants, students, and others interested in the potato industry will come to understand the pathogen, disease symptoms, epidemiology, and management strategies associated with this worldwide disease of potato. Pythium leak can be a major storage disease, and this presentation will discuss practices to limit issues in storage facilities. Development of resistance by the pathogen in the United States to the fungicide metalaxyl will be discussed, along with its implications.