This presentation will help U.S. potato consultants, growers, and other practitioners manage weeds across the crop rotation in a way that minimizes the risk for herbicide resistance development. Herbicide-resistant weeds pose significant economic and production challenges, particularly in specialty crops such as potatoes, for which weed-control options are already limited. This presentation will provide an update on herbicide-resistant weeds and a systematic way to assign herbicides to crops across the rotation in a manner that maintains weed control while utilizing multiple herbicide modes of action.