Plant-parasitic nematodes are among the most important yield-limiting pathogens that affect cotton and soybean production in the southern United States. Management consists of an integrated pest management system, which varies among nematode species. Thus, sampling for nematodes is an important step in managing cotton and soybean nematodes. This presentation will introduce crop rotation options, some available cultivars with resistance to root-knot nematode and efficacy and yield protection by seed- and soil-applied nematicides.